Recent Developments in Closed System Transfer Devices (CSTDs)

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According to the latest market research study published by P&S Intelligence, the global closed system transfer devices market will touch USD 3,516 million by 2030.

As the global population continues to grow, there is an increasing need for oncology drugs, because of the rising cases of cancer worldwide. Consequently, the number of healthcare workers involved in preparing and administering these hazardous medicines, as well as those working in areas with potential exposure to these agents, is also on the rise.

 

The surge in cancer cases has led to a higher requirement for effective treatment drugs. However, healthcare workers face potential risks of exposure to these medications through accidental ingestion, inhalation, needle stick injuries, and skin contact, which can result in serious health issues such as reproductive problems, leukemia, skin reactions, bone marrow impact, and fetal malformation.

 

To address these risks, the National Institute for Occupational Safety and Health (NIOSH) recommends the use of closed system transfer devices (CSTDs) to eliminate the potentially harmful reactions associated with handling hazardous drugs.

 

Understanding Closed System Transfer Devices

 

A closed system drug transfer device, also known as a CSTD, is a mechanism designed to prevent the leakage of dangerous drugs or vapor concentrations outside the system and the transfer of environmental contaminants into the system. In medical devices, closed systems are commonly employed to maintain the sterility of fluid pathways.

 

CSTDs work by effectively controlling the inflow and outflow of contaminants and drugs, thus preserving the quality of the solutions being administered to patients.

 

Initially developed for use with cancer drugs, CSTDs are now being utilized in other areas, including the administration of antiviral drugs, hormone agents, and bioengineered medications.

 

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Expanding Applications of CSTDs

 

With the high pathogenicity of viral infections and limited effective treatments, the risk of contamination is particularly concerning. CSTDs offer a valuable solution, allowing the safe preparation of liquid or pre-dissolved powder medicines in flexible bottles, syringes, or infusion bags while maintaining product sterility and preventing hazardous drug escape and environmental contamination. This has led to the wider adoption of CSTDs with various types of drugs, expanding their applications in the healthcare sector.

 

Primary Users of CSTDs

 

Hospitals and clinics are the primary users of CSTDs, given the substantial number of cancer patients requiring treatment and care across numerous healthcare facilities. As a result, a significant number of healthcare workers come into direct contact with hazardous drugs.

 

High Utilization of Membrane-to-Membrane CSTDs

 

Among different types of CSTDs, membrane-to-membrane devices are notably popular due to their ease of use and reduced risk of contamination compared to needleless devices. The volume loss associated with these double-membrane CSTDs is also minimal.

 

However, needleless CSTDs are gaining traction, thanks to their advantages such as needle-free transfer of medication. Many companies are launching new products, contributing to the increasing adoption of needleless devices.

 

Additionally, among the various component of CSTDs namely vial access devices, bag/line access devices, syringe safety devices, and accessories. Vial access devices are the most widely used components of CSTDs. Nurses extensively use these devices to transfer hazardous drugs, particularly antineoplastic drugs, from vials into the patient's infusion chamber.

 

With the rising incidence of cancer cases and increased healthcare investments in Asian nations, the utilization of CSTDs is expected to continue growing. By the end of this decade, the demand for CSTD will reach a value of USD 3,516 million.

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